Cancer is a major global health concern, and is one of the leading causes of mortality in many developed countries including Australia. Most of the morbidity and mortality associated with cancer can be linked to the process of metastasis, whereby malignant cancerous cells move from their primary site to establish secondary tumours at a distant location. The capacity of cells to migrate through a tissue depends on their ability to degrade the extracellular matrix. Matrix metalloproteinases are the main protease enzymes involved in the degradation of the extracellular matrix. The release of these enzymes is important, not just for normal immune and inflammatory processes, but also for cancer.
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