CLINICAL RESEARCH
Prior aspirin and/or nonsteroidal anti-inflammatory drug use in sepsis patients is associated with reduced intensive care unit morbidity and mortality: retrospective study
Submission date: 2018-07-11
Final revision date: 2018-09-14
Acceptance date: 2018-09-18
Publication date: 2018-12-17
Arch Med Sci Civil Dis 2018;3(1):147-152
KEYWORDS
quick sequential organ failure assessmentsequential organ failure assessmentnonsteroidal anti-inflammatory drugaspirinmortality
TOPICS
ABSTRACT
Introduction:
Sepsis is a life-threatening condition that is characterized by multi-organ dysfunction and a high mortality rate, and prevention may be cheaper and easier than treatment. The sequential organ failure assessment (SOFA) score is associated with mortality risk, and the Quick SOFA (qSOFA) is a shortened version. In this study, we examined whether there was any difference between the qSOFA and SOFA scores, procalcitonin and CRP levels, and mortality among patients with sepsis who either used or did not use aspirin and/or nonsteroidal anti-inflammatory drug (NSAID).
Material and methods:
This study was designed as a retrospective analysis of 64 septic patients, 38 males and 26 females. SOFA, qSOFA and APACHE II scores, as well as gender, age, length of hospital stay, procalcitonin and CRP levels, blood culture results, mortality rates and the use of aspirin and/or NSAID were recorded from the files.
Results:
The median age of aspirin and/or NSAID users was 63 years and of non-users was 55. There were significant differences in the SOFA scores and mortality rates between aspirin and/or NSAID users and non-NSAID/aspirin users (p < 0.05). There were no significant differences in the length of hospital stay or blood culture results (p > 0.05). There were also significant differences in CRP and procalcitonin values (p < 0.05).
Conclusions:
In this study, patients that used aspirin and/or NSAID had lower SOFA, qSOFA and APACHE II scores and lower mortality rates. There have been recent studies on the prevention of sepsis in patients having already used these drugs before hospital admission, but there have been no publications in which sepsis is supported by SOFA and qSOFA scores with aspirin and/or NSAID users.
Sepsis is a life-threatening condition that is characterized by multi-organ dysfunction and a high mortality rate, and prevention may be cheaper and easier than treatment. The sequential organ failure assessment (SOFA) score is associated with mortality risk, and the Quick SOFA (qSOFA) is a shortened version. In this study, we examined whether there was any difference between the qSOFA and SOFA scores, procalcitonin and CRP levels, and mortality among patients with sepsis who either used or did not use aspirin and/or nonsteroidal anti-inflammatory drug (NSAID).
Material and methods:
This study was designed as a retrospective analysis of 64 septic patients, 38 males and 26 females. SOFA, qSOFA and APACHE II scores, as well as gender, age, length of hospital stay, procalcitonin and CRP levels, blood culture results, mortality rates and the use of aspirin and/or NSAID were recorded from the files.
Results:
The median age of aspirin and/or NSAID users was 63 years and of non-users was 55. There were significant differences in the SOFA scores and mortality rates between aspirin and/or NSAID users and non-NSAID/aspirin users (p < 0.05). There were no significant differences in the length of hospital stay or blood culture results (p > 0.05). There were also significant differences in CRP and procalcitonin values (p < 0.05).
Conclusions:
In this study, patients that used aspirin and/or NSAID had lower SOFA, qSOFA and APACHE II scores and lower mortality rates. There have been recent studies on the prevention of sepsis in patients having already used these drugs before hospital admission, but there have been no publications in which sepsis is supported by SOFA and qSOFA scores with aspirin and/or NSAID users.
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| ISSN: | 2451-0637 |
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