CLINICAL RESEARCH
The relation between smoking and smoker timing and diabetic complications in type 2 diabetes mellitus patients
More details
Hide details
Submission date: 2018-08-11
Acceptance date: 2018-10-06
Publication date: 2018-12-10
Arch Med Sci Civil Dis 2018;3(1):95-102
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Active and passive smoking are the main causes of preventable diseases and deaths worldwide, and pose a serious public health problem. In many studies, it has been shown that smoking increases the risk of type 2 diabetes mellitus (DM) development and is associated with bad glycemic control and development of diabetic complications in diabetic patients. Our aim in the present study was to examine the relation between smoking and diabetic complications in type 2 DM patients.
Material and methods:
A total of 757 patients who were followed up with type 2 DM diagnosis were included in the present study. The demographic and anthropometric features, diabetic complications, smoking history and when the patients quit smoking were recorded. The relation between smoking and diabetic complications was also investigated.
Results:
A total of 54.8% (415 patients) of the patients did not smoke; 12% (91 patients) had quit smoking; and 33.2% (251 patients) were still smoking. There was a statistically significant relation between smoking and male gender, waist circumference, glycated hemoglobin (HbA1c) level, lifestyle, drug compliance, hypertension and diabetic complications. There was a statistically significant relation between smoking quitting period and male gender, HbA1c level, waist circumference, lifestyle, drug compliance and diabetic complications.
Conclusions:
A significant relation was observed between smoking and microvascular and macrovascular complications. It was shown that after quitting smoking, bad glycemic control and complications diminished in time. Smoking in diabetic patients is the most important risk factor that may be changed.
REFERENCES (25)
1.
Satman I, Imamoglu S, Yılmaz C, Akalın S ve Diabetes Mellitus Study and Training Group. TEMD Diabetes Mellitus and it’s Complications Diagnosis, Treatment and Monitoring Guide, 5. Printing. Bayt Typography, Ankara, 2011.
2.
Hilton DJ, OÕRourke PK, Welborn TA, Reid CM. Diabetes detection in Australian general practise: a comparison of diagnostic criteria. Med J Aust 2002; 176: 104-7.
3.
da Rocha Fernandes J, Ogurtsova K, Linnenkamp U, et al. IDF Diabetes Atlas estimates of 2014 global health expenditures on diabetes. Diabetes Res Clin Pract 2016; 117: 48-54.
4.
The TURDEP Group. Population-Based Study of Diabetes and Risk Characteristics in Turkey. Diabetes Care 2002; 25: 1551-6.
5.
Satman I; the TURDEP Group. Population-Based Study of Diabetes and Risk Characteristics in Turkey. 32. Türkiye Endokrinoloji ve Metabolizma Hastalıkları Kongresi özet kitabı,13-17 Ekim 2010, Antalya, 2010; 24-9.
6.
Menzin J, Langley-Hawthor C, Friedman M, Boulanger L, Cavanaugh R. Potential short-term economic benefits of improved glycemic control: a managed care perspective. Diabetes Care 2001; 24: 51-5.
7.
International Expert Committee. International Expert Committee report on the role of the A1c assay in the diagnosis of diabetes. Diabetes Care 2009; 32: 1327-34.
8.
WHO Report on the Global Tobacco Epidemic, MPOWER, WHO, 2008.
9.
Global Adult Tobacco Survey, Turkey Report, Ministry of Health, Publ. 2 July 2010.
10.
Carlsson S, Midthjell K, Grill V. Smoking is associated with an increased risk of type 2 diabetes but a decreased risk of autoimmune diabetes in adults: an 11-year follow-up of incidence of diabetes in the Nord-Trondelag study. Diabetologia 2004; 47: 1953-6.
11.
Willi C, Bodenmann P, Ghali WA, Faris PD, Cornuz J. Active smoking and the risk of type 2 diabetes: a systematic review and meta-analysis. JAMA 2007; 298: 2654-64.
12.
Smith U, Axelsen M, Carvalho E, Eliasson B, Jansson PA, Wesslau C. Insulin signaling and action in fat cells: associations with insulin resistance and type 2 diabetes. Ann N Y Acad Sci 1999; 892: 119-26.
13.
American Diabetes Association. Standards of Medical Care in Diabetes. Diabetes Care 2015; 38: 8-67.
14.
Summary of Revisions for the 2009 Clinical Practice Recommendations. Diabetes Care 2009; 32: 754.
15.
Yoshikawa H, Hellstrom-Lindahl E, Grill V. Evidence for functional nicotinic receptors on pancreatic beta cells. Metabolism 2005; 54: 247-54.
16.
Bruin JE, Gerstein HC, Morrison KM, Holloway AC. Increased pancreatic beta-cell apoptosis following fetal and neonatal exposure to nicotine is mediated via the mitochondria. Toxicol Sci 2008; 103: 362-70.
17.
Chakkarwar VA. Smoking in diabetic nephropathy: sparks in the fuel tank?. World J Diabetes 2012; 3: 186-95.
18.
Halimi JM, Giraudeau B, Vol S, et al. Effects of current smoking and smoking discontinuation on renal function and proteinuria in the general population. Kidney Int 2000; 58: 1285-92.
19.
Zheng Y, He M, Congdon N. The worldwide epidemic of diabetic retinopathy. Indian J Ophthalmol 2012; 60: 428-31.
20.
Boretsky A, Gupta P, Tirgan N, et al. Nicotine accelerates diabetes-induced retinal changes. Curr Eye Res 2015; 40: 368-77.
21.
Hu R, Zhang XX, Wang WQ, Lau CP, Tse HF. Smoking, homocysteine and degree of arteriolar retinopathy. Atherosclerosis 2005; 183: 95-100.
22.
Clair C, Cohen MJ, Eichler F, Selby KJ, Rigotti NA. The effect of cigarette smoking on diabetic peripheral neuropathy: a systematic review and meta-analysis. J Gen Intern Med 2015; 30: 1193-203.
23.
Mitchell BD, Hawthorne VM, Vinik AI. Cigarette smoking and neuropathy in diabetic patients. Diabetes Care 1990; 13: 434-7.
24.
Phipps MS, Jastreboff AM, Furie K, Kernan WN. The diagnosis and management of cerebrovascular disease in diabetes. Curr Diab Rep 2012; 12: 314-23.
25.
Yusuf S, Reddy S, Ôunpuu S, Anand S. Global burden of cardiovascular diseases: part i: general considerations, the epidemiologic transition, risk factors, and impact of urbanization. Circulation 2001; 104: 2746-53.