EXPERIMENTAL RESEARCH
Hydroxytyrosol has a cardioprotective effect through dardarin and asprosin
1
Department of Histology and Embryology, Faculty of Medicine, Fırat University, Elazığ, Turkey
2
Department of Medical Pharmacology, Faculty of Medicine, Adıyaman University, Adıyaman, Turkey
Submission date: 2024-03-10
Acceptance date: 2024-07-24
Publication date: 2024-09-25
Corresponding author
Elif Onat
Department of Medical Pharmacology, Faculty of Medicine, Adıyaman University, Adıyaman, Turkey
Department of Medical Pharmacology, Faculty of Medicine, Adıyaman University, Adıyaman, Turkey
Arch Med Sci Civil Dis 2024;9(1):1-6
KEYWORDS
TOPICS
ABSTRACT
Introduction:
In this investigation, we explored the potential involvement of dardarin (LRRK2) and asprosin in the protective efficacy of hydroxytyrosol (HT) against heart damage induced by corn syrup in rats.
Material and methods:
The research was conducted at the Adıyaman University Experimental Research Center during the period from December 8, 2021, to July 12, 2023. Rats were categorized into four groups (n = 6) as follows: control, HT, corn syrup, and corn syrup + HT. Over a span of 6 weeks, rats were administered water infused with 30% corn syrup. Simultaneously, a 4 ml/kg/day solution containing HT was orally administered, both independently and in conjunction with corn syrup, throughout the 6-week period. The molecular parameters of LRRK2 and asprosin in the cardiac tissue were assessed through histopathological examination.
Results:
In this study, it was observed that the LRRK2 level increased and the asprosin level decreased in the control group as a result of administration of corn syrup. After HT treatment, the LRRK2 level decreased non-significantly, while the asprosin level increased significantly. No difference was seen in the HT-only group compared to the control.
Conclusions:
The protective effect of HT against damage to the heart due to corn syrup consumption may be mediated by LRRK2 and asprosin.
In this investigation, we explored the potential involvement of dardarin (LRRK2) and asprosin in the protective efficacy of hydroxytyrosol (HT) against heart damage induced by corn syrup in rats.
Material and methods:
The research was conducted at the Adıyaman University Experimental Research Center during the period from December 8, 2021, to July 12, 2023. Rats were categorized into four groups (n = 6) as follows: control, HT, corn syrup, and corn syrup + HT. Over a span of 6 weeks, rats were administered water infused with 30% corn syrup. Simultaneously, a 4 ml/kg/day solution containing HT was orally administered, both independently and in conjunction with corn syrup, throughout the 6-week period. The molecular parameters of LRRK2 and asprosin in the cardiac tissue were assessed through histopathological examination.
Results:
In this study, it was observed that the LRRK2 level increased and the asprosin level decreased in the control group as a result of administration of corn syrup. After HT treatment, the LRRK2 level decreased non-significantly, while the asprosin level increased significantly. No difference was seen in the HT-only group compared to the control.
Conclusions:
The protective effect of HT against damage to the heart due to corn syrup consumption may be mediated by LRRK2 and asprosin.
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| ISSN: | 2451-0637 |
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