EXPERIMENTAL RESEARCH
Effects of vitamin E, methylprednisolone and nedocromil sodium on healing of rats with experimentally created intraabdominal adhesions
1
Department of General Surgery, Antalya Medical Park Hospital, Antalya, Turkey
2
Department of General Surgery, Firat University Hospital, Elazig, Turkey
Submission date: 2020-05-04
Final revision date: 2020-07-04
Acceptance date: 2020-07-25
Publication date: 2020-11-13
Arch Med Sci Civil Dis 2020;5(1):48-52
KEYWORDS
TOPICS
ABSTRACT
Introduction:
Intraabdominal adhesions are a condition that can occur after many surgical procedures and may cause complications in a spectrum ranging from simple abdominal pain to ileus. For years, efforts have been made to prevent this complication. In this experimental study, the effects of methylprednisolone, vitamin E and nedocromil sodium on the improvement of intraabdominal adhesions in rats were investigated.
Material and methods:
Twenty Wistar Albino rats weighing 280 to 330 g were divided into four equal groups. 5 ml of 0.9% NaCl was given to the control group, 5 ml of methylprednisolone was given to group 2, 5 ml of vitamin E to group 3 and 5 ml of nedocromil sodium to group 4 were given intraabdominally. On the 14th postoperative day, all rats were sacrificed and re-laparotomy was performed. Intraabdominal adhesions were scored according to the Nair classification.
Results:
When the groups were compared dyadically, the difference between group 1 and group 2 was found to be statistically significant (p = 0.011). The difference between group 1 and group 3 was statistically significant (p = 0.011). The difference between group 1 and group 4 was statistically significant (p = 0.007). There was no statistically significant difference between group 2 and group 3, and group 2 and group 4, and group 3 and group 4 (p < 0.05).
Conclusions:
As a result, methylprednisolone, vitamin E and nedocromil sodium have been shown to have a healing effect on adhesions.
Intraabdominal adhesions are a condition that can occur after many surgical procedures and may cause complications in a spectrum ranging from simple abdominal pain to ileus. For years, efforts have been made to prevent this complication. In this experimental study, the effects of methylprednisolone, vitamin E and nedocromil sodium on the improvement of intraabdominal adhesions in rats were investigated.
Material and methods:
Twenty Wistar Albino rats weighing 280 to 330 g were divided into four equal groups. 5 ml of 0.9% NaCl was given to the control group, 5 ml of methylprednisolone was given to group 2, 5 ml of vitamin E to group 3 and 5 ml of nedocromil sodium to group 4 were given intraabdominally. On the 14th postoperative day, all rats were sacrificed and re-laparotomy was performed. Intraabdominal adhesions were scored according to the Nair classification.
Results:
When the groups were compared dyadically, the difference between group 1 and group 2 was found to be statistically significant (p = 0.011). The difference between group 1 and group 3 was statistically significant (p = 0.011). The difference between group 1 and group 4 was statistically significant (p = 0.007). There was no statistically significant difference between group 2 and group 3, and group 2 and group 4, and group 3 and group 4 (p < 0.05).
Conclusions:
As a result, methylprednisolone, vitamin E and nedocromil sodium have been shown to have a healing effect on adhesions.
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| ISSN: | 2451-0637 |
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